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3‑Oxoacyl-[acyl-carrier-protein] Synthase I (None)
- Target
- None
- Molecular classification
- Enzyme, Acyltransferase
01
Overview
3‑Oxoacyl-[acyl-carrier-protein] synthase I (KAS I or FabB) is a key enzyme in type II fatty acid synthesis (FAS II), catalyzing the condensation reaction that elongates fatty acid chains by adding two carbons from malonyl-ACP to an acyl-ACP substrate. This process is essential for the biosynthesis of long-chain fatty acids, critical for cell membranes and energy storage. It is a homodimeric protein using a conserved catalytic triad—His-His-Cys.
- Other names
- Beta-ketoacyl-ACP synthaseKASIFabBOXSM (human)EC 2.3.1.41
02
Mechanism of action
Cerulenin covalently binds to the active site cysteine residue, blocking enzymatic activity
03
Biological functions
Fatty acid biosynthesisChain elongation
04
Disease associations
Infection
05
Safety considerations
Inhibition can disrupt fatty acid metabolism
06
Interacting drugs
Cerulenin
6 more in the full profile.
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